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Pamoic acid disodium

CAS No. 6640-22-8

Pamoic acid disodium( —— )

Catalog No. M33901 CAS No. 6640-22-8

Pamoic acid disodium is a GPR35 agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 29 In Stock
25MG 44 In Stock
50MG 63 In Stock
100MG 88 In Stock
200MG 131 In Stock
500MG 219 In Stock
1G 322 In Stock
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Biological Information

  • Product Name
    Pamoic acid disodium
  • Note
    Research use only, not for human use.
  • Brief Description
    Pamoic acid disodium is a GPR35 agonist.
  • Description
    Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect.
  • In Vitro
    Western Blot AnalysisCell Line:U2OS cells Concentration:1, 10, 100 nM and 1, 10 μM Incubation Time:15 min Result:A concentration-dependent activation of ERK1/2 was observed with an EC50 of 65 nM.
  • In Vivo
    Animal Model:Swiss-Webster mice (30–35 g)Dosage:25, 50, and 100 mg/kg Administration:Subcutaneous injection, once Result:Elicited dose-related antinociception, the dose causing 50% antinociception being 40.5 mg/kg.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6640-22-8
  • Formula Weight
    411.36
  • Molecular Formula
    C23H16NaO6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (231.30 mM; Ultrasonic (<60°C)
  • SMILES
    [Na+].[Na+].Oc1c(cc2ccccc2c1Cc1c(O)c(cc2ccccc12)C([O-])=O)C([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8.?
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